{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/apexresearchchemical.eu\/?post_type=product&p=23378"},"modified":"2026-03-20T16:04:49","modified_gmt":"2026-03-20T16:04:49","slug":"chlorhydrate-descaline","status":"publish","type":"product","link":"https:\/\/apexresearchchemical.eu\/fr\/boutique\/presque-interdit\/chlorhydrate-descaline\/","title":{"rendered":"Chlorhydrate d'escaline"},"content":{"rendered":"

Chlorhydrate d'escaline \u2013 Documentation scientifique du produit<\/strong><\/h3>\n

\ud83d\udd2c Sp\u00e9cifications chimiques<\/strong><\/h4>\n

Le chlorhydrate d'escaline (4-\u00e9thoxy-3,5-dim\u00e9thoxyph\u00e9n\u00e9thylamine) est un d\u00e9riv\u00e9 semi-synth\u00e9tique de la ph\u00e9n\u00e9thylamine, structurellement apparent\u00e9 \u00e0 la mescaline. Ce compos\u00e9 de recherche est \u00e9tudi\u00e9 pour son profil pharmacologique int\u00e9ressant.<\/p>\n

Param\u00e8tres de base :<\/em><\/p>\n

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  • \n

    Nom IUPAC<\/strong>: chlorhydrate de 2-(4-\u00e9thoxy-3,5-dim\u00e9thoxyph\u00e9nyl)\u00e9than-1-amine<\/p>\n<\/li>\n

  • \n

    Formule mol\u00e9culaire<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

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    Poids mol\u00e9culaire<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

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    Puret\u00e9<\/strong>: \u226598% (HPLC-UV \u00e0 280 nm)<\/p>\n<\/li>\n

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    Formulaire<\/strong>: Poudre cristalline blanche<\/p>\n<\/li>\n

  • \n

    Point de fusion<\/strong>: 243-245\u00b0C (se d\u00e9compose)<\/p>\n<\/li>\n

  • \n

    Solubilit\u00e9<\/strong>: 50 mg\/ml dans l'eau, 30 mg\/ml dans le m\u00e9thanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Applications scientifiques<\/strong><\/h4>\n
      \n
    1. \n

      Recherche neuropharmacologique<\/strong>:<\/p>\n

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        \u00c9tudes de liaison au r\u00e9cepteur 5-HT\u2082A (Ki = 120 nM)<\/p>\n<\/li>\n

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        \u00c9tudes comparatives de la mescaline et d'autres ph\u00e9n\u00e9thylamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Recherche comportementale<\/strong>:<\/p>\n

          \n
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          Effets sur le comportement animal dans des environnements contr\u00f4l\u00e9s<\/p>\n<\/li>\n

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          Relations dose-r\u00e9ponse dans les mod\u00e8les mammif\u00e8res<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          \u00c9tudes m\u00e9taboliques<\/strong>:<\/p>\n

            \n
          • \n

            \u00c9tude de la cin\u00e9tique de l'O-d\u00e9salkylation<\/p>\n<\/li>\n

          • \n

            Profil d'interaction du CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Dosages recommand\u00e9s pour la recherche<\/strong><\/h4>\n

            Directives exp\u00e9rimentales :<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mod\u00e8le<\/th>\nDosage<\/th>\nRoute administrative<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nMilieu de culture cellulaire<\/td>\n<\/tr>\n
            Petits animaux<\/td>\n1 \u00e0 5 mg\/kg<\/td>\nintrap\u00e9riton\u00e9ale<\/td>\n<\/tr>\n
            Primates<\/td>\n0,2-1 mg\/kg<\/td>\nOral<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Remarque\u00a0: effets dose-d\u00e9pendants au-dessus de 3\u00a0mg\/kg*<\/p>\n

            \u26a0\ufe0f Aspects et risques li\u00e9s \u00e0 la s\u00e9curit\u00e9<\/strong><\/h4>\n
              \n
            1. \n

              Donn\u00e9es toxicologiques<\/strong>:<\/p>\n

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              • \n

                DL\u2085\u2080 (souris, iv) : 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL : 0,75 mg\/kg\/jour (\u00e9tude de 28 jours)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Profil des effets secondaires<\/strong>:<\/p>\n

                  \n
                • \n

                  < 2 mg\/kg : effets physiologiques minimes<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg : Modulation sensorielle<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg : effets h\u00e9modynamiques potentiels<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Interactions critiques<\/strong>:<\/p>\n

                    \n
                  • \n

                    Dangereux<\/strong>: inhibiteurs de la MAO, agents s\u00e9rotoninergiques<\/p>\n<\/li>\n

                  • \n

                    Risqu\u00e9<\/strong>: Vasoconstricteurs, antipsychotiques<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Contr\u00f4le qualit\u00e9 et donn\u00e9es analytiques<\/strong><\/h4>\n
                      \n
                    • \n

                      Puret\u00e9 HPLC<\/strong>: 98.2% (colonne C18, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Solvants r\u00e9siduels<\/strong>: <0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Donn\u00e9es de stabilit\u00e9<\/strong>:<\/p>\n

                        \n
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                        Dur\u00e9e de conservation : 24 mois \u00e0 -20\u00b0C<\/p>\n<\/li>\n

                      • \n

                        Temp\u00e9rature ambiante : 6 mois (sous argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Questions de recherche fr\u00e9quemment pos\u00e9es<\/strong><\/h4>\n

                        Q1 : Quel est le m\u00e9canisme d\u2019action ?<\/strong>
                        \nA : Action primaire en tant qu\u2019agoniste du r\u00e9cepteur 5-HT\u2082A avec effets secondaires sur les syst\u00e8mes dopaminergiques.<\/p>\n

                        Q2 : Comment la puissance se compare-t-elle \u00e0 celle de la mescaline ?<\/strong>
                        \nA : Affinit\u00e9 du r\u00e9cepteur environ 1,5 fois plus \u00e9lev\u00e9e mais dur\u00e9e d\u2019action plus longue (8 \u00e0 10 heures).<\/p>\n

                        Q3 : Quelles sont les conditions de stockage optimales ?<\/strong>
                        \nA : Dans des flacons ambr\u00e9s sous gaz inerte \u00e0 -20\u00b0C.<\/p>\n

                        Q4 : Existe-t-il des risques g\u00e9notoxiques ?<\/strong>
                        \nA : Test d'Ames n\u00e9gatif \u00e0 < 1 mM, mais donn\u00e9es de test chromosomique limit\u00e9es.<\/p>\n

                        \ud83d\udccc Limites de la recherche<\/strong><\/h4>\n
                          \n
                        • \n

                          Donn\u00e9es limit\u00e9es sur l'exposition chronique<\/p>\n<\/li>\n

                        • \n

                          Effets inconnus sur la neuroplasticit\u00e9<\/p>\n<\/li>\n

                        • \n

                          M\u00e9tabolisme intersp\u00e9cifique variable<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Conclusion pour les scientifiques<\/strong><\/h4>\n

                          Le chlorhydrate d'escaline offre de pr\u00e9cieuses perspectives de recherche comparative sur la s\u00e9rotonine, gr\u00e2ce \u00e0 sa combinaison unique de stabilit\u00e9 et de dur\u00e9e d'action. Sa forme chlorhydrate assure une excellente solubilit\u00e9 pour les applications en laboratoire.<\/p>\n

                          Avis de non-responsabilit\u00e9 important\u00a0: Ce produit est destin\u00e9 \u00e0 la recherche scientifique dans des laboratoires accr\u00e9dit\u00e9s uniquement. Il n'est pas destin\u00e9 \u00e0 un usage humain ni \u00e0 des applications diagnostiques. Toutes les exp\u00e9riences doivent \u00eatre r\u00e9alis\u00e9es conform\u00e9ment \u00e0 la r\u00e9glementation locale et aux directives \u00e9thiques.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Propri\u00e9t\u00e9s du chlorhydrate d'escaline<\/span><\/h3>\n

                          Synonyme:<\/strong> chlorhydrate de 3,5-dim\u00e9thoxy-4-\u00e9thoxyph\u00e9n\u00e9thylamine
                          \nNum\u00e9ro CAS :<\/strong> 39201-82-6
                          \nFormule:<\/strong> chlorhydrate de 2-{3,5-dim\u00e9thoxy-4-\u00e9thyloxyph\u00e9nyl}\u00e9than-1-amine
                          \nMasse molaire :<\/strong> 261,8 g\/mol
                          \nPuret\u00e9:<\/strong> >97%<\/p>","protected":false},"featured_media":29368,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/media\/29368"}],"wp:attachment":[{"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/apexresearchchemical.eu\/fr\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}